Endocrine Abstracts

Vitamin D is a lipid-soluble hormone found in certain foods and synthesized from precursors in the skin when exposed to ultraviolet light. Vitamin D plays a critical role in bone metabolism and many cellular and immunological processes; and low levels have been associated with several chronic and infectious diseases. Vitamin D status is assessed by measuring the concentration of serum 25-hydroxy vitamin D (25(OH) D). Vitamin D deficiency is reported to be common worldwide, but...

Osteoprotogerin (OPG) and the receptor activators of nuclear factor-kβ (RANK) and nuclear factor-kβ ligand (RANKL) play an important role in bone metabolism. RANKL binds to RANK, which is expressed by osteoclasts, whereas OPG acts as its decoy receptor, blocking the RANK–RANKL interaction.The aim of our study was to evaluate bone turnover parameters (serum calcium, phosphorus, alkaline phosphatase, parathormone, osteocalcine, 24-...

Background: Hashimoto’s thyroiditis is a chronic autoimmune thyroiditis. It is the most common cause of primary hypothyroidism in adolescent period, via autoimmune thyroid tissue destruction and affecting 2% of the population. In this study we want to investigate the role of the cytokines such as IL-2, IL-12, TNF-α and IFN-γ in the pathogenesis of the disease and the changes of cytokine levels with the L-thyroxine treatment....

Thyroid hormones play an important role in bone metabolism. The potential action of prolonged levothyroxine therapy on bone mass reduction is stil a matter of debate.The aim of our one year prospective study was to elucidate whether longterm suppressive thyroid hormone therapy in patient with differentiated thyroid cancer (DTC) affects bone metabolism, osteoprotegerin (OPG) and soluble receptor activator of nuclear factor kβ ligand (sRANK-L) and is ...

Hyperprolactinaemia can occur in patients with primary hypothyroidism. Although its prevalence in overt hypothyroidism varies from 0 to 40%, its prevalence and clinical significance in subclinical hypothyroidism has not been studied. In this prospective, observational study, serum levels of prolactin (PRL) were measured in 167 consecutive patients presenting to our endocrinology clinic for evaluation of hypothyroidism, and correlation of PRL levels with the severity of hypothy...

Background/AimsGender affirming hormone therapy (GAHT) has been reported to have positive psychosocial effects on transgender people. In present study, we aimed to investigate longitudinally the short-term and long-term impacts on social adaptation, body image, features of alexithymia and aggression changes in transgender men after GAHT administration.MethodsThe single center, longitudinally follow-up study i...

Background/Aim: In literature, many previous studies adressed that Gender-affirmig Hormone Therapy (GAHT) improves the factors affecting social functioning such as self-esteem, mental well-being, behavioral health and quality of life. In this study, we aimed to quantitatively evaluate the effects of the GAHT on social functioning using a psychiatric scale in people with female-to-male (FtM) in Türkiye.Methods: The single center, cross-sectional stud...